Seward Rutkove Laboratory

The Laboratory of Seward B. Rutkove, MD, at Beth Israel Deaconess Medical Center and Harvard Medical School focuses on translational research for the development of novel diagnostics and therapeutics to help treat neuromuscular diseases and improve muscle and nerve health.  

Our lab focuses on a broad range of neuromuscular disorders, including:

  • amyotrophic lateral sclerosis
  • muscular dystrophy
  • spinal muscular atrophy
  • polyneuropathies, including diabetic neuropathy
  • inflammatory myopathies
  • radiculopathy
  • localized nerve problems/compressions.

Much of our work involves the application of electrophysiological measures and innovative bioengineering approaches to diagnose and treat these disorders. We are also interested in studying mechanisms of disease pathogenesis and testing new therapeutic agents.  

The primary techniques used in our lab are electrical impedance myography (EIM) and quantitative ultrasound (QUS). Both of these techniques are showing value in a wide variety of neuromuscular conditions and are being refined continuously.  

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